Peripheral Blood Markers Associated with Immune-Related Adverse Effects in Patients Who Had Advanced Non-Small Cell Lung Cancer Treated with PD-1 Inhibitors

Wenhui Liu,1,2 Yiping Liu,1,2 Fang Bike Parts - Tires - 27" Ma,3 Bao Sun,1,2 Ying Wang,1,2 Jianquan Luo,1,2 Mouze Liu,1,2 Zhiying Luo1,2 1Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Institute of Clinical Pharmacy, Central South University, Changsha, People’s Repub

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A Unique Gene Module in Thermococcales Archaea Centered on a Hypervariable Protein Containing Immunoglobulin Domains

Molecular mechanisms involved in biological conflicts and self vs nonself recognition in archaea remain poorly characterized.We apply phylogenomic analysis to identify a hypervariable gene module that is widespread among Thermococcales.These loci consist of an upstream gene coding for a large protein containing several immunoglobulin (Ig) domains a

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O antigen biogenesis sensitises Escherichia coli K-12 to bile salts, providing a plausible explanation for its evolutionary loss.

Escherichia coli K-12 is a model organism for bacteriology and has served as a workhorse for molecular biology and biochemistry for over a century since its first isolation in 1922.However, Escherichia coli K-12 strains are phenotypically devoid of an O antigen (OAg) since early reports in the scientific literature.Recent studies have reported the

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